Malcolm Sayer (Robin Williams) is a neurologist assigned to work with a group of patients in a Bronx, New York hospital who have been in a catatonic state for decades due to an outbreak of encephalitis lethargica. It also raises questions about the nature of consciousness and human mind mysteries. The film delves into themes such as hope, compassion, and the limitations of medical treatment. Most of the patients eventually return to their catatonic state, though one patient, Leonard, played by Robert De Niro, is able to hold onto his awakening for a little longer before succumbing to it. However, as the film progresses, the patients begin to experience medication side effects, and their condition worsens. Their lives are transformed as they begin to communicate with each other and with their families. To his surprise, the drug works, and the patients are “awakened” from their coma. Sayer is captivated by these patients and begins experimenting with a new drug known as L-Dopa, which was originally developed to treat Parkinson’s disease. He encounters a group of patients who have been catatonic for decades, unable to communicate or interact with the outside world.
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